AvESel Plus

A Unique Innovative product from

the Netherlands

What’s AvESel Plus?

AvESel Plus is a well-balanced and stabilized liquid solution of Chelated Zinc, Selenium, and Vitamin E, as an intensive synergistic mixture, developed by Avesafe R&D team in 2015 as the 1st product in the market.

It contains 100’000 mg Vit E, 15’000 mg Zinc, and 240 mg Selenium per liter.

Zinc is one of the most important nutrients in animal metabolism. It is needed everywhere within the body which there is an intensive cell proliferation like as reproductive system, immune system, epithelial cells, etc.  So it can be used as a dietary supplement to keep the birds in healthy condition and good performance. Zincdeficiencies result in suppressed immune system, poor feathering and dermatitis, infertility and poor egg shell quality.

The effect of Selenium in poultry nutrition is associated with its participation in the anti-oxidation reactions of the cells. Selenium is an important part in the structure of the molecule of glutathione peroxidase enzyme, which acts in the cell as the main frontline of defense against oxidative agents.  So it carries an important role in prevention of oxidative reactions like as exudative diathesis, normal pancreatic function, fertility, etc.

Vitamin E is a fat soluble antioxidant that protects the lipid cell membranes from the effects of oxidation and well recognized as Selenium synergism.

Recent research suggested synergistic effect of the combinations of Selenium, vitamin E and Zinc in the diets in comparison with use each of them alone.


How to Use:

1 liter in 1000 liter of Drinking Water. Special protocols for different farm conditions will be sent in case of need.



Benefits of AvESel Plus:

  • Unique formulation with fine adjusted amounts based on the latest researches.
  • Highly and easily soluble in water with very good stability before and after dilution.
  • One of the best absorbable form of Selenium, Zinc and vitamin E.

AvESel Plus Helps birds in:

  • Immunity system (specific humoral and cell-mediated immune responses) in infections (bacterial and viral).
  • Reproductive performance
  • Stress resistant especially in Heat Stress
  • Stimulation of appetite, body weight gains and feed intake
  • Support skeletal development
  • Wound healing, skin, feather and paw problems
  • to battle with Ascites syndrome

For more information please send email;

Scientific References and Review:


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Biol Trace Elem Res. 2004 Nov;101(2):147-63.

  • The role of zinc in life: a review.

Frassinetti S1Bronzetti GCaltavuturo LCini MCroce CD.

J Environ Pathol Toxicol Oncol. 2006;25(3):597-610.

  • Zinc: Nutritional and Pharmacological Roles

Larry L. Berger

  • Nutrition and the immune system.

Klasing KC1.

Br Poult Sci. 2007 Oct;48(5):525-37.

  • Managing gut health through nutrition.

Choct M1.

Br Poult Sci. 2009 Jan;50(1):9-15. doi: 10.1080/00071660802538632.

  • Nutritional aspect of zinc availability.

Cámara F1Amaro MA.

Int J Food Sci Nutr. 2003 Mar;54(2):143-51.

  • Selenium influence in the poultry immune response--review.

Saad MB1Gertner LRBona TDSantin E.

Recent Pat Food Nutr Agric. 2009 Nov;1(3):243-7.

  • Effects of feeding different forms of zinc and copper on the performance and tissue mineral content of chicks.

Ao T1Pierce JLPower RPescatore AJCantor AHDawson KAFord MJ.

Poult Sci. 2009 Oct;88(10):2171-5. doi: 10.3382/ps.2009-00117.

  • Selenium as a feed supplement for heat-stressed poultry: a review.

Habibian M1Sadeghi GGhazi SMoeini MM.

Biol Trace Elem Res. 2015 Jun;165(2):183-93. doi: 10.1007/s12011-015-0275-x. Epub 2015 Feb 27.

  • Role of dietary zinc in heat-stressed poultry: a review.

Sahin K1Sahin NKucuk OHayirli APrasad AS.

Poult Sci. 2009 Oct;88(10):2176-83. doi: 10.3382/ps.2008-00560.

  • Zinc deficiency.

Tuerk MJ1Fazel N.

Curr Opin Gastroenterol. 2009 Mar;25(2):136-43. doi: 10.1097/MOG.0b013e328321b395.

  • Early intestinal growth and development in poultry.

Lilburn MS1Loeffler S2.

Poult Sci. 2015 Jul;94(7):1569-76. doi: 10.3382/ps/pev104. Epub 2015 Apr 23.

  • Zinc metabolism in airway epithelium and airway inflammation: basic mechanisms and clinical targets. A review.

Zalewski PD1Truong-Tran AQGrosser DJayaram LMurgia CRuffin RE.

Pharmacol Ther. 2005 Feb;105(2):127-49. Epub 2004 Nov 10.

  • An optimal dietary zinc level of broiler chicks fed a corn-soybean meal diet.

Huang YL1Lu LLuo XGLiu B.

Poult Sci. 2007 Dec;86(12):2582-9.

  • Association of mitochondrial function and feed efficiency in poultry and livestock species.

Bottje WG1Carstens GE.

J Anim Sci. 2009 Apr;87(14 Suppl):E48-63. doi: 10.2527/jas.2008-1379. Epub 2008 Nov 21.

  • Modulating the immune response by oral zinc supplementation: a single approach for multiple diseases.

Overbeck S1Rink LHaase H.

Arch Immunol Ther Exp (Warsz). 2008 Jan-Feb;56(1):15-30. doi: 10.1007/s00005-008-0003-8. Epub 2008 Feb 5.

  • Zinc status and immune system relationship: a review.

Salgueiro MJ1Zubillaga MLysionek ACremaschi GGoldman CGCaro RDe Paoli THager AWeill RBoccio J.

Biol Trace Elem Res. 2000 Sep;76(3):193-205.

  • Immunobiology of gestational zinc deficiency.

Wellinghausen N1.

Br J Nutr. 2001 May;85 Suppl 2:S81-6.

  • Zinc and the immune system.

Rink L1Gabriel P.

Proc Nutr Soc. 2000 Nov;59(4):541-52.

  • The immune system: a target for functional foods?

Calder PC1Kew S.

Br J Nutr. 2002 Nov;88 Suppl 2:S165-77.

  • Modulation of the avian immune system: suppression versus induction of immunity.

Rautenschlein S1Neumann U.

Pol J Vet Sci. 2004;7(1):39-46.

  • Impact of dietary components on chicken immune system and Salmonella infection.

Babu US1Raybourne RB.

Expert Rev Anti Infect Ther. 2008 Feb;6(1):121-35. doi: 10.1586/14787210.6.1.121.

  • Effects of Higher Levels of Zinc Supplementation on Performance, Mineral Availability, and Immune Competence in Broiler Chickens 
  1. Shyam SunderA. K. PandaN. C. S. Gopinath S. V. Rama RaoM. V. L. N. Raju M. R. Reddy Ch. Vijay Kumar

The Journal of Applied Poultry Research, Volume 17, Issue 1, 1 March 2008, Pages 79–86,

  • The activity and use of zinc in poultry diets
  1. NAZ(a1)M. IDRIS(a2)M.A. KHALIQUE (a3)ZIA-UR-RAHMAN (a4) ...




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